d-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception

We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of d-cystine diethyl ester (d-cystine diEE) or d-cystine dimethyl ester (d-cystine diME) on morphine-induced changes in ventilation, arterial-bloo...

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Detalles Bibliográficos
Autores principales: Gaston, Benjamin, Baby, Santhosh M., May, Walter J., Young, Alex P., Grossfield, Alan, Bates, James N., Seckler, James M., Wilson, Christopher G., Lewis, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113454/
https://www.ncbi.nlm.nih.gov/pubmed/33976311
http://dx.doi.org/10.1038/s41598-021-89455-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113454/
https://www.ncbi.nlm.nih.gov/pubmed/33976311
http://dx.doi.org/10.1038/s41598-021-89455-2

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