FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer

Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1 immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a highly glycosylated protein. However, the mechanisms of B7H3 glycosylation regulation and whether the sugar moiety contribut...

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Detalles Bibliográficos
Autores principales: Huang, Yun, Zhang, Hai-Liang, Li, Zhi-Ling, Du, Tian, Chen, Yu-Hong, Wang, Yan, Ni, Huan-He, Zhang, Kai-Ming, Mai, Jia, Hu, Bing-Xin, Huang, Jun-Hao, Zhou, Li-Huan, Yang, Dong, Peng, Xiao-Dan, Feng, Gong-Kan, Tang, Jun, Zhu, Xiao-Feng, Deng, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113546/
https://www.ncbi.nlm.nih.gov/pubmed/33976130
http://dx.doi.org/10.1038/s41467-021-22618-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113546/
https://www.ncbi.nlm.nih.gov/pubmed/33976130
http://dx.doi.org/10.1038/s41467-021-22618-x

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