The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of other inflammatory diseases. Therefore, IL-1β activity must be fine-tuned to enable anti-microbial responses whilst limiting collateral damage. Here, we show that precurso...

Descripción completa

Detalles Bibliográficos
Autores principales: Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113568/
https://www.ncbi.nlm.nih.gov/pubmed/33976225
http://dx.doi.org/10.1038/s41467-021-22979-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113568/
https://www.ncbi.nlm.nih.gov/pubmed/33976225
http://dx.doi.org/10.1038/s41467-021-22979-3

Ejemplares similares