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In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors

Gene manipulation is a useful approach for understanding functions of genes and is important for investigating basic mechanisms of brain function on the level of single neurons and circuits. Despite the development and the wide range of applications of CRISPR-Cas9 and base editors (BEs), their imple...

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Detalles Bibliográficos
Autores principales: Song, Beomjong, Kang, Chan Young, Han, Jun Hee, Kano, Masanobu, Konnerth, Arthur, Bae, Sangsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113754/
https://www.ncbi.nlm.nih.gov/pubmed/34025938
http://dx.doi.org/10.1016/j.csbj.2021.04.051