Epilepsy-Associated UBE3A Deficiency Downregulates Retinoic Acid Signalling Pathway

Ubiquitin-protein ligase E3A (UBE3A) has dual functions as a E3 ubiquitin-protein ligase and coactivator of nuclear hormone receptors. Mutations or deletions of the maternally inherited UBE3A gene cause Angelman syndrome. Here, we performed transcriptome profiling in the hippocampus of Ube3a(m+/p+)...

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Detalles Bibliográficos
Autores principales: Fang, Meimiao, Li, Yali, Ren, Jin, Hu, Ronggui, Gao, Xiaobo, Chen, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113777/
https://www.ncbi.nlm.nih.gov/pubmed/33995501
http://dx.doi.org/10.3389/fgene.2021.681295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113777/
https://www.ncbi.nlm.nih.gov/pubmed/33995501
http://dx.doi.org/10.3389/fgene.2021.681295

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