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Epilepsy-Associated UBE3A Deficiency Downregulates Retinoic Acid Signalling Pathway
Ubiquitin-protein ligase E3A (UBE3A) has dual functions as a E3 ubiquitin-protein ligase and coactivator of nuclear hormone receptors. Mutations or deletions of the maternally inherited UBE3A gene cause Angelman syndrome. Here, we performed transcriptome profiling in the hippocampus of Ube3a(m+/p+)...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113777/ https://www.ncbi.nlm.nih.gov/pubmed/33995501 http://dx.doi.org/10.3389/fgene.2021.681295 |