Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma

Antitubercular lanostane triterpenoids isolated from mycelial cultures of the basidiomycete Ganoderma australe were structurally modified by semisynthesis. One of the synthetic compounds, named GA003 (9), showed more potent activity against Mycobacterium tuberculosis H37Ra than the lead natural lano...

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Autores principales: Chinthanom, Panida, Vichai, Vanicha, Dokladda, Kanchana, Sappan, Malipan, Thongpanchang, Chawanee, Isaka, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113785/
https://www.ncbi.nlm.nih.gov/pubmed/33981028
http://dx.doi.org/10.1038/s41429-021-00422-5
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author Chinthanom, Panida
Vichai, Vanicha
Dokladda, Kanchana
Sappan, Malipan
Thongpanchang, Chawanee
Isaka, Masahiko
author_facet Chinthanom, Panida
Vichai, Vanicha
Dokladda, Kanchana
Sappan, Malipan
Thongpanchang, Chawanee
Isaka, Masahiko
author_sort Chinthanom, Panida
collection PubMed
description Antitubercular lanostane triterpenoids isolated from mycelial cultures of the basidiomycete Ganoderma australe were structurally modified by semisynthesis. One of the synthetic compounds, named GA003 (9), showed more potent activity against Mycobacterium tuberculosis H37Ra than the lead natural lanostane (1). GA003 was also significantly active against the virulent strain (H37Rv) as well as extensively drug-resistant tuberculosis strains.
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spelling pubmed-81137852021-05-12 Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma Chinthanom, Panida Vichai, Vanicha Dokladda, Kanchana Sappan, Malipan Thongpanchang, Chawanee Isaka, Masahiko J Antibiot (Tokyo) Article Antitubercular lanostane triterpenoids isolated from mycelial cultures of the basidiomycete Ganoderma australe were structurally modified by semisynthesis. One of the synthetic compounds, named GA003 (9), showed more potent activity against Mycobacterium tuberculosis H37Ra than the lead natural lanostane (1). GA003 was also significantly active against the virulent strain (H37Rv) as well as extensively drug-resistant tuberculosis strains. Nature Publishing Group UK 2021-05-12 2021 /pmc/articles/PMC8113785/ /pubmed/33981028 http://dx.doi.org/10.1038/s41429-021-00422-5 Text en © The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Chinthanom, Panida
Vichai, Vanicha
Dokladda, Kanchana
Sappan, Malipan
Thongpanchang, Chawanee
Isaka, Masahiko
Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma
title Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma
title_full Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma
title_fullStr Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma
title_full_unstemmed Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma
title_short Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma
title_sort semisynthetic modifications of antitubercular lanostane triterpenoids from ganoderma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113785/
https://www.ncbi.nlm.nih.gov/pubmed/33981028
http://dx.doi.org/10.1038/s41429-021-00422-5
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