Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network

SHP2 is a ubiquitous protein tyrosine phosphatase, whose activity is regulated by phosphotyrosine (pY)-containing peptides generated in response to extracellular stimuli. Its crystal structure reveals a closed, auto-inhibited conformation in which the N-terminal Src homology 2 (N-SH2) domain occlude...

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Detalles Bibliográficos
Autores principales: Marasco, Michelangelo, Kirkpatrick, John, Nanna, Vittoria, Sikorska, Justyna, Carlomagno, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113834/
https://www.ncbi.nlm.nih.gov/pubmed/34025932
http://dx.doi.org/10.1016/j.csbj.2021.04.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113834/
https://www.ncbi.nlm.nih.gov/pubmed/34025932
http://dx.doi.org/10.1016/j.csbj.2021.04.040

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