Nonphosphorylated tau slows down Aβ(1–42) aggregation, binds to Aβ(1–42) oligomers, and reduces Aβ(1–42) toxicity

The formation of neurofibrillary tangles and amyloid plaques accompanies the progression of Alzheimer's disease. Tangles are made of fibrillar aggregates formed by the microtubule-associated protein tau, whereas plaques comprise fibrillar forms of amyloid-beta (Aβ). Both form toxic oligomers du...

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Detalles Bibliográficos
Autores principales: Beeg, Marten, Battocchio, Elisabetta, De Luigi, Ada, Colombo, Laura, Natale, Carmina, Cagnotto, Alfredo, Corbelli, Alessandro, Fiordaliso, Fabio, Diomede, Luisa, Salmona, Mario, Gobbi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113980/
https://www.ncbi.nlm.nih.gov/pubmed/33865852
http://dx.doi.org/10.1016/j.jbc.2021.100664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113980/
https://www.ncbi.nlm.nih.gov/pubmed/33865852
http://dx.doi.org/10.1016/j.jbc.2021.100664

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