Ultralow amounts of DNA from long-term archived serum samples produce high-quality methylomes

BACKGROUND: Long-term stored serum is considered challenging for epigenomic analyses: as there are no cells, circulating DNA is scarce, and amplification removes epigenetic signals. Additionally, pre-analytical treatments and storage might introduce biases and fragmentation to the DNA. In particular...

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Detalles Bibliográficos
Autores principales: Wojewodzic, Marcin W., Leithaug, Magnus, Lauritzen, Marianne, Lyle, Robert, Haglund, Sofia, Rubin, Carl-Johan, Ewels, Philip A., Grotmol, Tom, Rounge, Trine B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114536/
https://www.ncbi.nlm.nih.gov/pubmed/33980276
http://dx.doi.org/10.1186/s13148-021-01097-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114536/
https://www.ncbi.nlm.nih.gov/pubmed/33980276
http://dx.doi.org/10.1186/s13148-021-01097-3

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