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Ultralow amounts of DNA from long-term archived serum samples produce high-quality methylomes
BACKGROUND: Long-term stored serum is considered challenging for epigenomic analyses: as there are no cells, circulating DNA is scarce, and amplification removes epigenetic signals. Additionally, pre-analytical treatments and storage might introduce biases and fragmentation to the DNA. In particular...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114536/ https://www.ncbi.nlm.nih.gov/pubmed/33980276 http://dx.doi.org/10.1186/s13148-021-01097-3 |