Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease

Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain sections. Mitochondrial dysfunction, particularl...

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Detalles Bibliográficos
Autores principales: Chen, Chun, McDonald, David, Blain, Alasdair, Sachdeva, Ashwin, Bone, Laura, Smith, Anna L. M., Warren, Charlotte, Pickett, Sarah J., Hudson, Gavin, Filby, Andrew, Vincent, Amy E., Turnbull, Doug M., Reeve, Amy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115071/
https://www.ncbi.nlm.nih.gov/pubmed/33980828
http://dx.doi.org/10.1038/s41531-021-00182-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115071/
https://www.ncbi.nlm.nih.gov/pubmed/33980828
http://dx.doi.org/10.1038/s41531-021-00182-x

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