Cargando…
Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease
Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain sections. Mitochondrial dysfunction, particularl...
Autores principales: | Chen, Chun, McDonald, David, Blain, Alasdair, Sachdeva, Ashwin, Bone, Laura, Smith, Anna L. M., Warren, Charlotte, Pickett, Sarah J., Hudson, Gavin, Filby, Andrew, Vincent, Amy E., Turnbull, Doug M., Reeve, Amy K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115071/ https://www.ncbi.nlm.nih.gov/pubmed/33980828 http://dx.doi.org/10.1038/s41531-021-00182-x |
Ejemplares similares
-
Parkinson’s disease neurons exhibit alterations in mitochondrial quality control proteins
por: Chen, Chun, et al.
Publicado: (2023) -
Decoding mitochondrial heterogeneity in single muscle fibres by imaging mass cytometry
por: Warren, Charlotte, et al.
Publicado: (2020) -
Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue
por: Sachdeva, Ashwin, et al.
Publicado: (2022) -
Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?()
por: Reeve, Amy, et al.
Publicado: (2014) -
Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence?
por: Chen, Chun, et al.
Publicado: (2019)