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Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
Endothelial barrier integrity is ensured by the stability of the adherens junction (AJ) complexes comprised of vascular endothelial (VE)-cadherin as well as accessory proteins such as β-catenin and p120-catenin. Disruption of the endothelial barrier due to disassembly of AJs results in tissue edema...
Autores principales: | Kim, Young-Mee, Krantz, Sarah, Jambusaria, Ankit, Toth, Peter T., Moon, Hyung-Geun, Gunarathna, Isuru, Park, Gye Young, Rehman, Jalees |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115264/ https://www.ncbi.nlm.nih.gov/pubmed/33980844 http://dx.doi.org/10.1038/s41467-021-23047-6 |
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