Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex

Imidazole glycerol phosphate synthase (HisFH) is a heterodimeric bienzyme complex operating at a central branch point of metabolism. HisFH is responsible for the HisH-catalyzed hydrolysis of glutamine to glutamate and ammonia, which is then used for a cyclase reaction by HisF. The HisFH complex is a...

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Detalles Bibliográficos
Autores principales: Wurm, Jan Philip, Sung, Sihyun, Kneuttinger, Andrea Christa, Hupfeld, Enrico, Sterner, Reinhard, Wilmanns, Matthias, Sprangers, Remco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115485/
https://www.ncbi.nlm.nih.gov/pubmed/33980881
http://dx.doi.org/10.1038/s41467-021-22968-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115485/
https://www.ncbi.nlm.nih.gov/pubmed/33980881
http://dx.doi.org/10.1038/s41467-021-22968-6

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