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The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity

T follicular helper (Tfh) cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection. However, the molecular mechanism controlling Tfh cell differentiation is poorly understood. Here, through two mixed bone marrow chimeric experiments, we identified Peli...

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Detalles Bibliográficos
Autores principales: Huang, Xinfang, Hao, Shumeng, Liu, Junli, Huang, Yuanyuan, Liu, Manman, Xiao, Chunyuan, Wang, Yan, Pei, Siyu, Yu, Tao, Xu, Jing, Wang, Haikun, Dai, Dongfang, Su, Xiao, Xiao, Yichuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115645/
https://www.ncbi.nlm.nih.gov/pubmed/33707688
http://dx.doi.org/10.1038/s41423-021-00660-5