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The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity
T follicular helper (Tfh) cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection. However, the molecular mechanism controlling Tfh cell differentiation is poorly understood. Here, through two mixed bone marrow chimeric experiments, we identified Peli...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115645/ https://www.ncbi.nlm.nih.gov/pubmed/33707688 http://dx.doi.org/10.1038/s41423-021-00660-5 |