Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy

Simlukafusp alfa (FAP-IL2v, RO6874281/RG7461) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAP) and an IL-2 variant with a retained affinity for IL-2Rβγ > IL-2 Rβγ and abolished binding to IL-2 Rα. Here, we investigated the immunostimulatory properties of F...

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Detalles Bibliográficos
Autores principales: Waldhauer, Inja, Gonzalez-Nicolini, Valeria, Freimoser-Grundschober, Anne, Nayak, Tapan K, Fahrni, Linda, Hosse, Ralf J., Gerrits, Danny, Geven, Edwin J. W., Sam, Johannes, Lang, Sabine, Bommer, Esther, Steinhart, Virginie, Husar, Elisabeth, Colombetti, Sara, Van Puijenbroek, Erwin, Neubauer, Markus, Cline, J. Mark, Garg, Pradeep K., Dugan, Gregory, Cavallo, Federica, Acuna, Gonzalo, Charo, Jehad, Teichgräber, Volker, Evers, Stefan, Boerman, Otto C., Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo, Klein, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115765/
https://www.ncbi.nlm.nih.gov/pubmed/33974508
http://dx.doi.org/10.1080/19420862.2021.1913791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115765/
https://www.ncbi.nlm.nih.gov/pubmed/33974508
http://dx.doi.org/10.1080/19420862.2021.1913791

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