The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands

CpG islands (CGIs) are key regulatory DNA elements at most promoters, but how they influence the chromatin status and transcription remains elusive. Here, we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. SAMD1 has an atypical winged-helix d...

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Detalles Bibliográficos
Autores principales: Stielow, Bastian, Zhou, Yuqiao, Cao, Yinghua, Simon, Clara, Pogoda, Hans-Martin, Jiang, Junyi, Ren, Yanpeng, Phanor, Sabrina Keita, Rohner, Iris, Nist, Andrea, Stiewe, Thorsten, Hammerschmidt, Matthias, Shi, Yang, Bulyk, Martha L., Wang, Zhanxin, Liefke, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115922/
https://www.ncbi.nlm.nih.gov/pubmed/33980486
http://dx.doi.org/10.1126/sciadv.abf2229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115922/
https://www.ncbi.nlm.nih.gov/pubmed/33980486
http://dx.doi.org/10.1126/sciadv.abf2229

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