T cell self-reactivity during thymic development dictates the timing of positive selection

Functional tuning of T cells based on their degree of self-reactivity is established during positive selection in the thymus, although how positive selection differs for thymocytes with relatively low versus high self-reactivity is unclear. In addition, preselection thymocytes are highly sensitive t...

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Detalles Bibliográficos
Autores principales: Lutes, Lydia K, Steier, Zoë, McIntyre, Laura L, Pandey, Shraddha, Kaminski, James, Hoover, Ashley R, Ariotti, Silvia, Streets, Aaron, Yosef, Nir, Robey, Ellen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116051/
https://www.ncbi.nlm.nih.gov/pubmed/33884954
http://dx.doi.org/10.7554/eLife.65435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116051/
https://www.ncbi.nlm.nih.gov/pubmed/33884954
http://dx.doi.org/10.7554/eLife.65435

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