De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases. Despite considerable efforts, it remains unclear how ABC transporters harness the chemical energy of ATP to drive substrate tran...

Descripción completa

Detalles Bibliográficos
Autores principales: Stefan, Erich, Obexer, Richard, Hofmann, Susanne, Vu Huu, Khanh, Huang, Yichao, Morgner, Nina, Suga, Hiroaki, Tampé, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116058/
https://www.ncbi.nlm.nih.gov/pubmed/33929325
http://dx.doi.org/10.7554/eLife.67732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116058/
https://www.ncbi.nlm.nih.gov/pubmed/33929325
http://dx.doi.org/10.7554/eLife.67732

Ejemplares similares