Withaferin-A Treatment Alleviates TAR DNA-Binding Protein-43 Pathology and Improves Cognitive Function in a Mouse Model of FTLD

Withaferin-A, an active withanolide derived from the medicinal herbal plant Withania somnifera induces autophagy, reduces TDP-43 proteinopathy, and improves cognitive function in transgenic mice expressing mutant TDP-43 modelling FTLD. TDP-43 is a nuclear DNA/RNA-binding protein with cellular functi...

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Detalles Bibliográficos
Autores principales: Kumar, Sunny, Phaneuf, Daniel, Julien, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116414/
https://www.ncbi.nlm.nih.gov/pubmed/33078279
http://dx.doi.org/10.1007/s13311-020-00952-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116414/
https://www.ncbi.nlm.nih.gov/pubmed/33078279
http://dx.doi.org/10.1007/s13311-020-00952-0

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