Intranasal Allopregnanolone Confers Rapid Seizure Protection: Evidence for Direct Nose-to-Brain Delivery

Allopregnanolone, a positive modulator of GABA(A) receptors with antiseizure activity, has potential in the treatment of seizure emergencies. Instillation of allopregnanolone in 40% sulfobutylether-β-cyclodextrin into the nose in mice rapidly elevated the seizure threshold in the timed intravenous p...

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Detalles Bibliográficos
Autores principales: Zolkowska, Dorota, Wu, Chun-Yi, Rogawski, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116426/
https://www.ncbi.nlm.nih.gov/pubmed/33405197
http://dx.doi.org/10.1007/s13311-020-00985-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116426/
https://www.ncbi.nlm.nih.gov/pubmed/33405197
http://dx.doi.org/10.1007/s13311-020-00985-5

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