Distinguishing Signal From Noise in Immunopeptidome Studies of Limiting-Abundance Biological Samples: Peptides Presented by I-A(b) in C57BL/6 Mouse Thymus

Antigen presentation by MHC-II proteins in the thymus is central to selection of CD4 T cells, but analysis of the full repertoire of presented peptides responsible for positive and negative selection is complicated by the low abundance of antigen presenting cells. A key challenge in analysis of limi...

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Detalles Bibliográficos
Autores principales: Nanaware, Padma P., Jurewicz, Mollie M., Clement, Cristina C., Lu, Liying, Santambrogio, Laura, Stern, Lawrence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116589/
https://www.ncbi.nlm.nih.gov/pubmed/33995376
http://dx.doi.org/10.3389/fimmu.2021.658601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116589/
https://www.ncbi.nlm.nih.gov/pubmed/33995376
http://dx.doi.org/10.3389/fimmu.2021.658601

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