ABCG2 Single Nucleotide Polymorphism Affects Imatinib Pharmacokinetics in Lower Alpha-1-Acid Glycoprotein Levels in Humans

Imatinib is transported extracellularly by ABCB1 and ABCG2 efflux transporters and bound to alpha-1-acid glycoprotein (AGP) in the bloodstream. However, the clinical and pharmacokinetic effects of ABCB1 and ABCG2 on imatinib were inconsistent in the previous literature and have not been confirmed. T...

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Detalles Bibliográficos
Autores principales: Park, Jin-Woo, Chung, Hyewon, Kim, Kyoung-Ah, Kim, Jong-Min, Park, In-Hwan, Lee, Sangjin, Park, Ji-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116740/
https://www.ncbi.nlm.nih.gov/pubmed/33995081
http://dx.doi.org/10.3389/fphar.2021.658039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116740/
https://www.ncbi.nlm.nih.gov/pubmed/33995081
http://dx.doi.org/10.3389/fphar.2021.658039

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