Cargando…

ABCG2 Single Nucleotide Polymorphism Affects Imatinib Pharmacokinetics in Lower Alpha-1-Acid Glycoprotein Levels in Humans

Imatinib is transported extracellularly by ABCB1 and ABCG2 efflux transporters and bound to alpha-1-acid glycoprotein (AGP) in the bloodstream. However, the clinical and pharmacokinetic effects of ABCB1 and ABCG2 on imatinib were inconsistent in the previous literature and have not been confirmed. T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jin-Woo, Chung, Hyewon, Kim, Kyoung-Ah, Kim, Jong-Min, Park, In-Hwan, Lee, Sangjin, Park, Ji-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116740/ https://www.ncbi.nlm.nih.gov/pubmed/33995081 http://dx.doi.org/10.3389/fphar.2021.658039

Ejemplares similares

Influence of FMO3 and CYP3A4 Polymorphisms on the Pharmacokinetics of Teneligliptin in Humans
por: Park, Jin-Woo, et al.
Publicado: (2021)

ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure
por: El Biali, Myriam, et al.
Publicado: (2021)

Rapid detection of FMO3 single nucleotide polymorphisms using a pyrosequencing method
por: Park, Jin-Woo, et al.
Publicado: (2022)

Effects of Simvastatin on Pharmacokinetics and Anticoagulant Effects of Dabigatran in Healthy Subjects
por: Chung, Hyewon, et al.
Publicado: (2023)

Gene Dose-Dependent and Additive Effects of ABCG2 rs2231142 and SLC2A9 rs3733591 Genetic Polymorphisms on Serum Uric Acid Levels
por: Park, Jin-Woo, et al.
Publicado: (2022)

Impact of ABCG2 and ABCB1 Polymorphisms on Imatinib Plasmatic Exposure: An Original Work and Meta-Analysis
por: Dalle Fratte, Chiara, et al.
Publicado: (2023)

Meta-Analysis of ABCG2 and ABCB1 Polymorphisms With Sunitinib-Induced Toxicity and Efficacy in Renal Cell Carcinoma
por: Sun, Fengjun, et al.
Publicado: (2021)

Single nucleotide polymorphisms in apoptosis pathway are associated with response to imatinib therapy in chronic myeloid leukemia
por: Zheng, Qiaoli, et al.
Publicado: (2016)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Cholic Acid (MT921) after a Subcutaneous Injection in the Submental Area to Humans
por: Chung, Hyewon, et al.
Publicado: (2021)

Macrophage inhibitory cytokine-1 aggravates diet-induced gallstone formation via increased ABCG5/ABCG8 expression
por: Kim, Min Hee, et al.
Publicado: (2023)

Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
por: Jang, Ji-Young, et al.
Publicado: (2012)

Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics
por: Adiwidjaja, Jeffry, et al.
Publicado: (2020)

Expression of ABCG2 (BCRP) in mouse models with enhanced erythropoiesis
por: Latunde-Dada, Gladys O., et al.
Publicado: (2014)

Research Progress on Leucine-Rich Alpha-2 Glycoprotein 1: A Review
por: Zou, Yonghui, et al.
Publicado: (2022)

OCT-1, ABCB1, and ABCG2 Expression in Imatinib-Resistant Chronic Myeloid Leukemia Treated with Dasatinib or Nilotinib
por: Kim, Yeo-Kyeoung, et al.
Publicado: (2014)

P-glycoprotein efflux transporter: a key to pharmacokinetic modeling for methadone clearance in fetuses
por: Ho, Harvey, et al.
Publicado: (2023)

Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration in Hanwoo, Korean native cattle
por: BELEW, Sileshi, et al.
Publicado: (2014)

Pharmacokinetics of a Fixed-Dose Combination Product of Dapagliflozin and Linagliptin and Its Comparison with Co-Administration of Individual Tablets in Healthy Humans
por: Park, Jin-Woo, et al.
Publicado: (2022)

Prospective Analysis in GIST Patients on the Role of Alpha-1 Acid Glycoprotein in Imatinib Exposure
por: Bins, Sander, et al.
Publicado: (2016)

Genetic Polymorphisms and Adverse Events on Unbound Imatinib and Its Active Metabolite Concentration in Patients With Gastrointestinal Stromal Tumors
por: Qian, Yi, et al.
Publicado: (2019)

Dexketoprofen Pharmacokinetics is not Significantly Altered by Genetic Polymorphism
por: Mejía-Abril, Gina, et al.
Publicado: (2021)

Elucidation of the Differences in Cinobufotalin’s Pharmacokinetics Between Normal and Diethylnitrosamine-Injured Rats: The Role of P-Glycoprotein
por: Zhang, Xiaojing, et al.
Publicado: (2019)

ABCG2 Gene Polymorphisms May Affect the Bleeding Risk in Patients on Apixaban and Rivaroxaban
por: Kim, Hamin, et al.
Publicado: (2023)

CYP3A5*3 and SLCO1B1 c.521T>C Polymorphisms Influence the Pharmacokinetics of Atorvastatin and 2-Hydroxy Atorvastatin
por: Park, Jin-Woo, et al.
Publicado: (2022)

Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo
por: Rajamani, Bharathi M., et al.
Publicado: (2023)

Decreased expression of alpha-2-HS glycoprotein in the sera of rats treated with Eurycoma longifolia extract
por: Chen, Yeng, et al.
Publicado: (2015)

Gene Polymorphisms Affecting the Pharmacokinetics and Pharmacodynamics of Donepezil Efficacy
por: Lu, Jin, et al.
Publicado: (2020)

Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population
por: Kim, Yun Sung, et al.
Publicado: (2015)

Y(6), an Epigallocatechin Gallate Derivative, Reverses ABCG2-Mediated Mitoxantrone Resistance
por: Zhao, Rui-Qiang, et al.
Publicado: (2019)

Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications
por: Toyoda, Yu, et al.
Publicado: (2019)

OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance
por: Yang, Yuqi, et al.
Publicado: (2021)

Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters
por: Annisa, Nurul, et al.
Publicado: (2022)

Transmembrane Domain Single-Nucleotide Polymorphisms Impair Expression and Transport Activity of ABC Transporter ABCG2
por: Sjöstedt, Noora, et al.
Publicado: (2017)

Studying the Impact of Presence of Alpha Acid Glycoprotein and Protein Glycoprotein in Chronic Myeloid Leukemia Patients Treated with Imatinib Mesylate in the State of Qatar
por: Al-Dewik, Nader I., et al.
Publicado: (2015)

ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity
por: Gauthier, Charlotte, et al.
Publicado: (2013)

Pharmacogenetic Aspects of the Interaction of AT1 Receptor Antagonists With ATP-Binding Cassette Transporter ABCG2
por: Ripperger, Anne, et al.
Publicado: (2018)

Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice
por: Gardner, Erin R, et al.
Publicado: (2009)

MicroRNA-212/ABCG2-axis contributes to development of imatinib-resistance in leukemic cells
por: Kaehler, Meike, et al.
Publicado: (2017)

Exacerbation of Psoriasis after Imatinib Mesylate Treatment
por: Shim, Joon Ho, et al.
Publicado: (2016)

Combination Therapy With Rapamycin and Low Dose Imatinib in Pulmonary Hypertension
por: Shi, Yinan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kc7a7ikhrd96np1q646m4krhq4