Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Proliferation of human lung fibroblasts in the pulmonary interstitial tissue is a hallmark of this disease and is driven by prolonged ERK signalling in the nucl...

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Detalles Bibliográficos
Autores principales: Roberts, Maxine J., May, Lauren T., Keen, Alastair C., Liu, Bonan, Lam, Terrance, Charlton, Steven J., Rosethorne, Elizabeth M., Halls, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116805/
https://www.ncbi.nlm.nih.gov/pubmed/33995100
http://dx.doi.org/10.3389/fphar.2021.669227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116805/
https://www.ncbi.nlm.nih.gov/pubmed/33995100
http://dx.doi.org/10.3389/fphar.2021.669227

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