7-Ethyl-10-Hydroxycamptothecin, a DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth

7-Ethyl-10-hydroxycamptothecin (SN-38) is an active metabolite of CPT-11, which can inhibit DNA topoisomerase I, DNA synthesis and cause frequent DNA single-strand breaks. In our study, SN-38 was characterized as a potent and reversible BRD4 inhibitor [IC(50) = 660.2 nM against BRD4 (BD1) and IC(50)...

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Detalles Bibliográficos
Autores principales: Wang, Airong, Li, Lingling, Li, Mengya, Wang, Shujuan, Wang, Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117000/
https://www.ncbi.nlm.nih.gov/pubmed/33995089
http://dx.doi.org/10.3389/fphar.2021.664176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117000/
https://www.ncbi.nlm.nih.gov/pubmed/33995089
http://dx.doi.org/10.3389/fphar.2021.664176

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