Plant derived coumestrol phytochemical targets human skin carcinoma cells by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and invasion and modulation of m-TOR/PI3K/AKT signalling pathway

The current study was undertaken to investigate anticancer activity of coumestrol phytoestrogen against human skin cancer. MTT assay was performed for cell viability assessment and clonogenic assay for cell colony formation assessment. Apoptosis was analysed by Annexin V/FITC staining, AO/EB stainin...

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Detalles Bibliográficos
Autores principales: Kuang, Weiwei, Hu, Wenlong, Ren, Hong, Shao, Yinhong, Liu, Bingqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117110/
https://www.ncbi.nlm.nih.gov/pubmed/34025159
http://dx.doi.org/10.1016/j.sjbs.2021.03.043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117110/
https://www.ncbi.nlm.nih.gov/pubmed/34025159
http://dx.doi.org/10.1016/j.sjbs.2021.03.043

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