LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy

Immune receptors expressed on TAMs are intriguing targets for tumor immunotherapy. In this study, we found inhibitory receptor LILRB4 on a variety of intratumoral immune cell types in murine tumor models and human cancers, most prominently on TAMs. LILRB4, known as gp49B in mice, is a LILRB family r...

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Detalles Bibliográficos
Autores principales: Sharma, Naveen, Atolagbe, Oluwatomisin T., Ge, Zhongqi, Allison, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117208/
https://www.ncbi.nlm.nih.gov/pubmed/33974041
http://dx.doi.org/10.1084/jem.20201811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117208/
https://www.ncbi.nlm.nih.gov/pubmed/33974041
http://dx.doi.org/10.1084/jem.20201811

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