Cbl-b deficiency prevents functional but not phenotypic T cell anergy

T cell anergy is an important peripheral tolerance mechanism. We studied how T cell anergy is established using an anergy model in which the Zap70 hypermorphic mutant W131A is coexpressed with the OTII TCR transgene (W131AOTII). Anergy was established in the periphery, not in the thymus. Contrary to...

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Detalles Bibliográficos
Autores principales: Nguyen, Trang T.T., Wang, Zhi-En, Shen, Lin, Schroeder, Andrew, Eckalbar, Walter, Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117209/
https://www.ncbi.nlm.nih.gov/pubmed/33974042
http://dx.doi.org/10.1084/jem.20202477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117209/
https://www.ncbi.nlm.nih.gov/pubmed/33974042
http://dx.doi.org/10.1084/jem.20202477

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