Cargando…

Cbl-b deficiency prevents functional but not phenotypic T cell anergy

T cell anergy is an important peripheral tolerance mechanism. We studied how T cell anergy is established using an anergy model in which the Zap70 hypermorphic mutant W131A is coexpressed with the OTII TCR transgene (W131AOTII). Anergy was established in the periphery, not in the thymus. Contrary to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Trang T.T., Wang, Zhi-En, Shen, Lin, Schroeder, Andrew, Eckalbar, Walter, Weiss, Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117209/ https://www.ncbi.nlm.nih.gov/pubmed/33974042 http://dx.doi.org/10.1084/jem.20202477

Ejemplares similares

Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency
por: Huemer, Martina, et al.
Publicado: (2016)

Spontaneous tumor rejection by cbl-b–deficient CD8(+) T cells
por: Loeser, Stefanie, et al.
Publicado: (2007)

A role for immunotherapy: preventing macrophage anergy in the tumour environment
por: Elia, Androulla, et al.
Publicado: (2013)

A novel CBL-B(flox/flox) mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells
por: Goetz, Benjamin, et al.
Publicado: (2016)

Lymphocyte Anergy in Patients with Carcinoma
por: Nind, A. P. P., et al.
Publicado: (1973)

Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells
por: Tong, Haijun, et al.
Publicado: (2021)

Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing
por: Li, Xin, et al.
Publicado: (2020)

Loss of the proapoptotic protein, Bim, breaks B cell anergy
por: Oliver, Paula M., et al.
Publicado: (2006)

Calcineurin B-Like Proteins CBL4 and CBL10 Mediate Two Independent Salt Tolerance Pathways in Arabidopsis
por: Yang, Yang, et al.
Publicado: (2019)

Role of CBL Mutations in Cancer and Non-Malignant Phenotype
por: Leardini, Davide, et al.
Publicado: (2022)

Targeting Cbl-b in cancer immunotherapy
por: Augustin, Ryan C., et al.
Publicado: (2023)

Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma
por: Carson, William F., et al.
Publicado: (2015)

Response: proliferative versus functional anergy
por: Charles, Edgar D., et al.
Publicado: (2011)

Clonal anergy of B cells: a flexible, reversible, and quantitative concept
Publicado: (1996)

Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy
por: Franks, S. Elizabeth, et al.
Publicado: (2018)

CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors
por: Kalekar, Lokesh A., et al.
Publicado: (2016)

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33
por: Tuncel, Jonatan, et al.
Publicado: (2019)

GRAIL: a gene related to anergy in lymphocytes
por: Fathman, G, et al.
Publicado: (2003)

Proteomic investigation of Cbl and Cbl-b in neuroblastoma cell differentiation highlights roles for SHP-2 and CDK16
por: Pedersen, Anna-Kathrine, et al.
Publicado: (2021)

Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease
por: Ono, Chisato, et al.
Publicado: (2023)

Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation
por: Fujiwara, Mai, et al.
Publicado: (2017)

Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy
por: An, Wei, et al.
Publicado: (2015)

Knockout of c-Cbl/Cbl-b slows c-Met trafficking resulting in enhanced signaling in corneal epithelial cells
por: Tarvestad-Laise, Kate, et al.
Publicado: (2023)

Role of Interleukin 12 and Costimulators in T Cell Anergy In Vivo
por: Parijs, Luk Van, et al.
Publicado: (1997)

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance
Publicado: (1995)

Models of T cell anergy: is there a common molecular mechanism?
Publicado: (1996)

Role of interleukin 12 and costimulators in T cell anergy in vivo
por: Van Parijs, Luk, et al.
Publicado: (2009)

Uncovering the mechanisms that regulate tumor-induced T-cell anergy
por: Abe, Brian T., et al.
Publicado: (2013)

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B
Publicado: (1990)

Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen
por: Taylor, Justin J., et al.
Publicado: (2012)

Impaired Control of Epstein–Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease
por: Arjunaraja, Swadhinya, et al.
Publicado: (2018)

A pathway of costimulation that prevents anergy in CD28- T cells: B7- independent costimulation of CD1-restricted T cells
Publicado: (1995)

Isoflurane decreases interleukin-2 production by increasing c-Cbl and Cbl-b expression in rat peripheral blood mononuclear cells
por: Choi, Ji Won, et al.
Publicado: (2018)

Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature
por: Singh, Tej Pratap, et al.
Publicado: (2018)

Overproduction of IL-2 by Cbl-b deficient CD4(+) T cells provides resistance against regulatory T cells
por: Han, SeongJun, et al.
Publicado: (2020)

SMAD4 Controls Cancer Cell Metabolism by Regulating Methylmalonic Aciduria Cobalamin Deficiency (cbl) B Type
por: Song, Kyoung, et al.
Publicado: (2022)

Intrinsic Plasma Cell Differentiation Defects in B Cell Expansion with NF-κB and T Cell Anergy Patient B Cells
por: Arjunaraja, Swadhinya, et al.
Publicado: (2017)

E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells()
por: Xu, Ling, et al.
Publicado: (2017)

Cbl-b predicts postoperative survival in patients with resectable pancreatic ductal adenocarcinoma
por: Dong, Qian, et al.
Publicado: (2017)

c-Cbl、Cbl-b和EGFR在非小细胞肺癌中的表达及其预后价值
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_331k08imk68ddn9qmnre4ol5ra