Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration

BACKGROUND: Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have emerged as a promising new therapeutic strategy for intervertebral disc degeneration (IVDD). However, the drawbacks of MSCs, including their invasive access, the donor age, and their limited proliferative capacity...

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Detalles Bibliográficos
Autores principales: Sun, Yongjin, Zhang, Wenzhi, Li, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117270/
https://www.ncbi.nlm.nih.gov/pubmed/33985571
http://dx.doi.org/10.1186/s13287-021-02362-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117270/
https://www.ncbi.nlm.nih.gov/pubmed/33985571
http://dx.doi.org/10.1186/s13287-021-02362-1

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