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Evolutionary history of sickle-cell mutation: implications for global genetic medicine
Resistance afforded by the sickle-cell trait against severe malaria has led to high frequencies of the sickle-cell mutation [HBB; c.20T>A, p.Glu6Val; OMIM: 141900 (HBB-β(S))] in most parts of Africa. High-coverage sequencing and genotype data have now confirmed the single African origin of the si...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117455/ https://www.ncbi.nlm.nih.gov/pubmed/33461216 http://dx.doi.org/10.1093/hmg/ddab004 |