Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome

Infections of the lower respiratory tract, such as pneumonia, are one of the leading causes of death worldwide. Streptococcus pneumoniae might colonize the upper respiratory tract and is the main aetiological agent of community-acquired pneumonia (CAP). In the last decades, several factors related t...

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Autores principales: Dietl, Beatriz, Henares, Desirée, Boix-Palop, Lucía, Muñoz-Almagro, Carmen, Garau, Javier, Calbo, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117960/
https://www.ncbi.nlm.nih.gov/pubmed/33996857
http://dx.doi.org/10.3389/fmed.2021.650271
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author Dietl, Beatriz
Henares, Desirée
Boix-Palop, Lucía
Muñoz-Almagro, Carmen
Garau, Javier
Calbo, Esther
author_facet Dietl, Beatriz
Henares, Desirée
Boix-Palop, Lucía
Muñoz-Almagro, Carmen
Garau, Javier
Calbo, Esther
author_sort Dietl, Beatriz
collection PubMed
description Infections of the lower respiratory tract, such as pneumonia, are one of the leading causes of death worldwide. Streptococcus pneumoniae might colonize the upper respiratory tract and is the main aetiological agent of community-acquired pneumonia (CAP). In the last decades, several factors related to the host, the microorganism and the antibiotic therapy have been investigated to identify risk factors associated with the development of invasive pneumococcal disease (IPD). Nevertheless, these factors themselves do not explain the risk of developing disease or its severity. Recently, some studies have focused on the importance of nasopharyngeal (NP) microbiome and its relation to respiratory health. This review presents existing evidence of the potential role of NP microbiome in the development of IPD.
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spelling pubmed-81179602021-05-14 Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome Dietl, Beatriz Henares, Desirée Boix-Palop, Lucía Muñoz-Almagro, Carmen Garau, Javier Calbo, Esther Front Med (Lausanne) Medicine Infections of the lower respiratory tract, such as pneumonia, are one of the leading causes of death worldwide. Streptococcus pneumoniae might colonize the upper respiratory tract and is the main aetiological agent of community-acquired pneumonia (CAP). In the last decades, several factors related to the host, the microorganism and the antibiotic therapy have been investigated to identify risk factors associated with the development of invasive pneumococcal disease (IPD). Nevertheless, these factors themselves do not explain the risk of developing disease or its severity. Recently, some studies have focused on the importance of nasopharyngeal (NP) microbiome and its relation to respiratory health. This review presents existing evidence of the potential role of NP microbiome in the development of IPD. Frontiers Media S.A. 2021-04-20 /pmc/articles/PMC8117960/ /pubmed/33996857 http://dx.doi.org/10.3389/fmed.2021.650271 Text en Copyright © 2021 Dietl, Henares, Boix-Palop, Muñoz-Almagro, Garau and Calbo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Dietl, Beatriz
Henares, Desirée
Boix-Palop, Lucía
Muñoz-Almagro, Carmen
Garau, Javier
Calbo, Esther
Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome
title Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome
title_full Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome
title_fullStr Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome
title_full_unstemmed Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome
title_short Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome
title_sort related factors to streptococcus pneumoniae invasive infection and clinical manifestations: the potential role of nasopharyngeal microbiome
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117960/
https://www.ncbi.nlm.nih.gov/pubmed/33996857
http://dx.doi.org/10.3389/fmed.2021.650271
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