Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways

BACKGROUND: The majority of pancreatic ductal adenocarcinomas (PDAC) are diagnosed at the metastatic stage, and standard therapies have limited activity with a dismal 5-year survival rate of only 8%. The liver and lung are the most common sites of PDAC metastasis, and each have been differentially a...

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Detalles Bibliográficos
Autores principales: Ho, Won Jin, Erbe, Rossin, Danilova, Ludmila, Phyo, Zaw, Bigelow, Emma, Stein-O’Brien, Genevieve, Thomas, Dwayne L., Charmsaz, Soren, Gross, Nicole, Woolman, Skylar, Cruz, Kayla, Munday, Rebecca M., Zaidi, Neeha, Armstrong, Todd D., Sztein, Marcelo B., Yarchoan, Mark, Thompson, Elizabeth D., Jaffee, Elizabeth M., Fertig, Elana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118107/
https://www.ncbi.nlm.nih.gov/pubmed/33985562
http://dx.doi.org/10.1186/s13059-021-02363-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118107/
https://www.ncbi.nlm.nih.gov/pubmed/33985562
http://dx.doi.org/10.1186/s13059-021-02363-6

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