Seeking the exclusive binding region of phenylalkylamine derivatives on human T‐type calcium channels via homology modeling and molecular dynamics simulation approach

Pharmaceutical features of phenylalkylamine derivatives (PAAs) binding to calcium channels have been studied extensively in the past decades. Only a few PAAs have the binding specificity on calcium channels, for example, NNC 55‐0396. Here, we created the homology models of human Ca(v)3.2, Ca(v)3.3 a...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, You, Li, Ming, Lee, Gi Young, Zhao, Na, Chen, Zhong, Edwards, Andrea, Zhang, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118199/
https://www.ncbi.nlm.nih.gov/pubmed/33984189
http://dx.doi.org/10.1002/prp2.783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118199/
https://www.ncbi.nlm.nih.gov/pubmed/33984189
http://dx.doi.org/10.1002/prp2.783

Ejemplares similares