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Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma
Patterns of cancer incidence, viewed over extended time periods, reveal important aspects of multistage carcinogenesis. Here we show how a multistage clonal expansion (MSCE) model for cancer can be harnessed to identify biological processes that shape the surprisingly dynamic and disparate incidence...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118544/ https://www.ncbi.nlm.nih.gov/pubmed/33939693 http://dx.doi.org/10.1371/journal.pcbi.1008961 |