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Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma

Patterns of cancer incidence, viewed over extended time periods, reveal important aspects of multistage carcinogenesis. Here we show how a multistage clonal expansion (MSCE) model for cancer can be harnessed to identify biological processes that shape the surprisingly dynamic and disparate incidence...

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Detalles Bibliográficos
Autores principales:	Luebeck, Georg E., Vaughan, Thomas L., Curtius, Kit, Hazelton, William D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118544/ https://www.ncbi.nlm.nih.gov/pubmed/33939693 http://dx.doi.org/10.1371/journal.pcbi.1008961

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