Propensity for somatic expansion increases over the course of life in Huntington disease

Recent work on Huntington disease (HD) suggests that somatic instability of CAG repeat tracts, which can expand into the hundreds in neurons, explains clinical outcomes better than the length of the inherited allele. Here, we measured somatic expansion in blood samples collected from the same 50 HD...

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Detalles Bibliográficos
Autores principales: Kacher, Radhia, Lejeune, François-Xavier, Noël, Sandrine, Cazeneuve, Cécile, Brice, Alexis, Humbert, Sandrine, Durr, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118653/
https://www.ncbi.nlm.nih.gov/pubmed/33983118
http://dx.doi.org/10.7554/eLife.64674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118653/
https://www.ncbi.nlm.nih.gov/pubmed/33983118
http://dx.doi.org/10.7554/eLife.64674

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