Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility

The COVID-19 pandemic has triggered concerns about the emergence of more infectious and pathogenic viral strains. As a public health measure, efficient screening methods are needed to determine the functional effects of new sequence variants. Here we show that structural modeling of SARS-CoV-2 Spike...

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Detalles Bibliográficos
Autores principales: Gan, Hin Hark, Twaddle, Alan, Marchand, Benoit, Gunsalus, Kristin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118711/
https://www.ncbi.nlm.nih.gov/pubmed/33992693
http://dx.doi.org/10.1016/j.jmb.2021.167051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118711/
https://www.ncbi.nlm.nih.gov/pubmed/33992693
http://dx.doi.org/10.1016/j.jmb.2021.167051

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