Cargando…

The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma

No effective systemic treatment is available for patients with unresectable, recurrent, or metastatic mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy. MEC is frequently associated with a t(11;19)(q14-21;p12-13) translocation that creates a CRTC1-MAML2 fusion gene. The CRTC1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zirong, Ni, Wei, Li, Jian-Liang, Lin, Shuibin, Zhou, Xin, Sun, Yuping, Li, Jennifer W., Leon, Marino E., Hurtado, Maria D., Zolotukhin, Sergei, Liu, Chen, Lu, Jianrong, Griffin, James D., Kaye, Frederic J., Wu, Lizi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119194/ https://www.ncbi.nlm.nih.gov/pubmed/33830080 http://dx.doi.org/10.1172/jci.insight.139497

Ejemplares similares

CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells
por: Chen, Zirong, et al.
Publicado: (2018)

Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells
por: Chen, Jie, et al.
Publicado: (2015)

Primary mucoepidermoid carcinoma of the liver with CRTC1-MAML2 fusion: a case report
por: Watanabe, Jiro, et al.
Publicado: (2019)

Mucoepidermoid carcinoma of the lacrimal gland in a patient with the CRTC1-MAML2 fusion gene
por: Makino, Kensaku, et al.
Publicado: (2021)

Mucoepidermoid carcinoma of the head and neck: CRTC1/3 MAML 2 translocation and its prognosticators
por: van Weert, Stijn, et al.
Publicado: (2021)

Establishment of a patient-derived mucoepidermoid carcinoma cell line with the CRTC1-MAML2 fusion gene
por: Noguchi, Kazuma, et al.
Publicado: (2022)

Prognostic impact of CRTC1/3‐MAML2 fusions in salivary gland mucoepidermoid carcinoma: A multiinstitutional retrospective study
por: Okumura, Yoshihide, et al.
Publicado: (2020)

Mucoepidermoid carcinoma of the salivary glands revisited with special reference to histologic grading and CRTC1/3-MAML2 genotyping
por: Fehr, André, et al.
Publicado: (2021)

Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma
por: Ni, Wei, et al.
Publicado: (2021)

Diagnostic Value of MAML2 Rearrangements in Mucoepidermoid Carcinoma
por: Thierauf, Julia C., et al.
Publicado: (2022)

Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation
por: Zhou, Xin, et al.
Publicado: (2021)

A Rare Case of Exclusively Oncocytic Mucoepidermoid Carcinoma with MAML2 Translocation
por: Liao, Xiaoyan, et al.
Publicado: (2016)

MAML2 Rearrangement in Primary Pulmonary Mucoepidermoid Carcinoma and the Correlation with FLT1 Expression
por: Zhu, Fen, et al.
Publicado: (2014)

Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report
por: Sato, Kiminobu, et al.
Publicado: (2017)

CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
por: Musicant, Adele M., et al.
Publicado: (2021)

MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler
por: Owosho, Adepitan A., et al.
Publicado: (2022)

MAML2 rearrangement as a useful diagnostic marker discriminating between Warthin tumour and Warthin-like mucoepidermoid carcinoma
por: Bieńkowski, Michał, et al.
Publicado: (2020)

MAML2-Rearranged Primary Central Mucoepidermoid Carcinoma of the Mandible as an Incidental Finding: A Case Report and Review of the Literature of Molecularly Confirmed Cases
por: Aguirre, Sarah E., et al.
Publicado: (2023)

Poromas with YAP1–MAML2 fusions in a poromatosis case
por: Yamamoto, Masako, et al.
Publicado: (2022)

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer
por: Komiya, Takefumi, et al.
Publicado: (2009)

YAP1-MAML2 Fusion as a Diagnostic Biomarker for Metaplastic Thymoma
por: Zhao, Jikai, et al.
Publicado: (2021)

Concomitant Pathogenic Mutations and Fusions of Driver Oncogenes in Tumors
por: Zhang, Runjiao, et al.
Publicado: (2021)

Novel role for the CRTC2 in lipid homeostasis
por: Matsuzaka, Takashi, et al.
Publicado: (2016)

Activation of the adipocyte CREB/CRTC pathway in obesity
por: Yoon, Young-Sil, et al.
Publicado: (2021)

YAP1-MAML2 fusion in a pediatric NF2-wildtype intraparenchymal brainstem schwannoma
por: Karajannis, Matthias A., et al.
Publicado: (2022)

Src kinase phosphorylates Notch1 to inhibit MAML binding
por: LaFoya, Bryce, et al.
Publicado: (2018)

Effects of the MAML2 genetic variants in glioma susceptibility and prognosis
por: Zhang, Ming, et al.
Publicado: (2019)

A Case of Digital Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Fusion
por: Bui, Chau M, et al.
Publicado: (2022)

Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer
por: Carper, Miranda B., et al.
Publicado: (2022)

Cell segmentation by multi-resolution analysis and maximum likelihood estimation (MAMLE)
por: Chowdhury, Sharif, et al.
Publicado: (2013)

Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity
por: Lubecka, Katarzyna, et al.
Publicado: (2016)

Pediatric meningioma with a Novel MAML2-YAP1 fusion variant: a case report and literature review
por: Zheng, Xuan, et al.
Publicado: (2022)

Mucoepidermoid carcinoma of the base of tongue
por: MESOLELLA, M., et al.
Publicado: (2015)

Pleomorphic adenomas and mucoepidermoid carcinomas of the breast are underpinned by fusion genes
por: Pareja, Fresia, et al.
Publicado: (2020)

Novel role of AMPK in cocaine reinforcement via regulating CRTC1
por: Liu, Xiao-Xing, et al.
Publicado: (2022)

Requirement of CRTC1 coactivator for hepatitis B virus transcription
por: Tang, Hei-Man Vincent, et al.
Publicado: (2014)

Sam68 promotes hepatic gluconeogenesis via CRTC2
por: Qiao, Aijun, et al.
Publicado: (2021)

Bronchial Mucoepidermoid Carcinoma
por: Gieraerts, Christopher, et al.
Publicado: (2016)

Identification and validation of PROM1 and CRTC2 mutations in lung cancer patients
por: He, Yanqi, et al.
Publicado: (2014)

A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP‐2
por: Li, Yujie, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jmcr3b0bj41e8r77rlvom69rdf