Cargando…

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells

Chronic inflammation and immune dysfunction play a key role in the development of non-AIDS–related comorbidities. The aim of our study was to characterize the functional phenotype of immune cells in people living with HIV (PLHIV). We enrolled a cross-sectional cohort study of PLHIV on stable antiret...

Descripción completa

Detalles Bibliográficos
Autores principales:	van der Heijden, Wouter A., Van de Wijer, Lisa, Keramati, Farid, Trypsteen, Wim, Rutsaert, Sofie, ter Horst, Rob, Jaeger, Martin, Koenen, Hans J.P.M., Stunnenberg, Hendrik G., Joosten, Irma, Verweij, Paul E., van Lunzen, Jan, Dinarello, Charles A., Joosten, Leo A.B., Vandekerckhove, Linos, Netea, Mihai G., van der Ven, André J.A.M., de Mast, Quirijn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119206/ https://www.ncbi.nlm.nih.gov/pubmed/33630761 http://dx.doi.org/10.1172/jci.insight.145928

Ejemplares similares

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation
por: Van de Wijer, Lisa, et al.
Publicado: (2021)

Targeted plasma proteomics reveals upregulation of distinct inflammatory pathways in people living with HIV
por: Vadaq, Nadira, et al.
Publicado: (2022)

People with HIV have higher percentages of circulating CCR5+ CD8+ T cells and lower percentages of CCR5+ regulatory T cells
por: van Eekeren, Louise E., et al.
Publicado: (2022)

Substance use, Unlike Dolutegravir, is Associated with Mood Symptoms in People Living with HIV
por: Van de Wijer, Lisa, et al.
Publicado: (2021)

Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV
por: Vadaq, Nadira, et al.
Publicado: (2022)

Clonal Hematopoiesis Is Associated With Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals With HIV
por: van der Heijden, Wouter A, et al.
Publicado: (2021)

Gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV
por: Zhang, Yue, et al.
Publicado: (2023)

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
por: Zhang, Zhenhua, et al.
Publicado: (2021)

The number of CCR5 expressing CD4+ T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors: a cross-sectional study
por: Meijerink, Hinta, et al.
Publicado: (2014)

Digital PCR as a tool to measure HIV persistence
por: Rutsaert, Sofie, et al.
Publicado: (2018)

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence
por: Lambrechts, Laurens, et al.
Publicado: (2020)

Long-term treated HIV infection is associated with platelet mitochondrial dysfunction
por: van der Heijden, Wouter A., et al.
Publicado: (2021)

Abacavir use is associated with increased prothrombin conversion
por: Yan, Qiuting, et al.
Publicado: (2023)

High-throughput proteomic analysis reveals systemic dysregulation in virally suppressed people living with HIV
por: Vadaq, Nadira, et al.
Publicado: (2023)

Ebola Virus Disease has Features of Hemophagocytic Lymphohistiocytosis Syndrome
por: van der Ven, Andre J. A. M., et al.
Publicado: (2015)

BCG vaccination is associated with reduced malaria prevalence in children under the age of 5 years in sub-Saharan Africa
por: Berendsen, Mike LT, et al.
Publicado: (2019)

In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes
por: Rutsaert, Sofie, et al.
Publicado: (2018)

Kallikrein augments the anticoagulant function of the protein C system in thrombin generation
por: Wan, Jun, et al.
Publicado: (2021)

Limited impact of impaired awareness of hypoglycaemia and severe hypoglycaemia on the inflammatory profile of people with type 1 diabetes
por: Ali, Namam, et al.
Publicado: (2020)

Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors
por: Van Hecke, Clarissa, et al.
Publicado: (2019)

On the whereabouts of SARS-CoV-2 in the human body: A systematic review
por: Trypsteen, Wim, et al.
Publicado: (2020)

Evaluating lncRNA Expression Patterns during HIV-1 Treatment Interruption
por: Schynkel, Tinus, et al.
Publicado: (2023)

Altered Ex-Vivo Cytokine Responses in Children With Asymptomatic Plasmodium falciparum Infection in Burkina Faso: An Additional Argument to Treat Asymptomatic Malaria?
por: Post, Annelies, et al.
Publicado: (2021)

Author Correction: Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
por: Stražar, Martin, et al.
Publicado: (2021)

Publisher Correction: Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
por: Stražar, Martin, et al.
Publicado: (2021)

Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
por: Stražar, Martin, et al.
Publicado: (2021)

Seasonal Variation in Vitamin D(3) Levels Is Paralleled by Changes in the Peripheral Blood Human T Cell Compartment
por: Khoo, Ai-Leng, et al.
Publicado: (2012)

Psychiatric symptoms in people living with HIV: prevalences, interactions and consequences
por: Meeder, E. M., et al.
Publicado: (2023)

The gut microbiome as mediator between diet and its impact on immune function
por: Shi, Huiqing, et al.
Publicado: (2022)

Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits
por: Aguirre-Gamboa, Raul, et al.
Publicado: (2016)

Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors
por: Temba, Godfrey S, et al.
Publicado: (2023)

Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37
por: van de Veerdonk, Frank L., et al.
Publicado: (2015)

Thyrotrophin and thyroxine support immune homeostasis in humans
por: Jaeger, Martin, et al.
Publicado: (2021)

Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis
por: Dewi, Intan M.W., et al.
Publicado: (2021)

Neurodevelopmental and behavioral consequences of perinatal exposure to the HIV drug efavirenz in a rodent model
por: van de Wijer, Lisa, et al.
Publicado: (2019)

Human uterine lymphocytes acquire a more experienced and tolerogenic phenotype during pregnancy
por: Feyaerts, Dorien, et al.
Publicado: (2017)

Diagnostic utility of droplet digital PCR for HIV reservoir quantification
por: Trypsteen, Wim, et al.
Publicado: (2016)

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses
por: Bakker, Olivier B., et al.
Publicado: (2018)

OR04-2 Aldosterone Induces Trained Immunity via Fatty Acid Synthesis
por: van der Heijden, Charlotte, et al.
Publicado: (2019)

Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report
por: van Meer, Maurits PA, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vp4o34oe522h0jb7k8jrvshk1l