Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

Despite the recent launch of tolvaptan, the search for safer polycystic kidney disease (PKD) drugs continues. Ciclopirox (CPX) or its olamine salt (CPX-O) is contained in a number of commercially available antifungal agents. CPX is also reported to possess anticancer activity. Several mechanisms of...

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Detalles Bibliográficos
Autores principales: Radadiya, Priyanka S., Thornton, Mackenzie M., Puri, Rajni V., Yerrathota, Sireesha, Dinh-Phan, Johnny, Magenheimer, Brenda, Subramaniam, Dharmalingam, Tran, Pamela V., Zhu, Hao, Bolisetty, Subhashini, Calvet, James P., Wallace, Darren P., Sharma, Madhulika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119220/
https://www.ncbi.nlm.nih.gov/pubmed/33784251
http://dx.doi.org/10.1172/jci.insight.141299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119220/
https://www.ncbi.nlm.nih.gov/pubmed/33784251
http://dx.doi.org/10.1172/jci.insight.141299

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