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Leptin activates Akt in oesophageal cancer cells via multiple atorvastatin-sensitive small GTPases

Obesity is a risk factor for Barrett’s oesophagus and oesophageal adenocarcinoma. Adipose tissue secretes the hormone leptin. Leptin is a growth factor for several cell types, including Barrett’s cells and oesophageal adenocarcinoma cells. Statins are associated with reduced rates of Barrett’s oesop...

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Detalles Bibliográficos
Autores principales: Beales, Ian L. P., Ogunwobi, Olorunseun O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119259/
https://www.ncbi.nlm.nih.gov/pubmed/33582946
http://dx.doi.org/10.1007/s11010-021-04067-8