Antigen-driven EGR2 expression is required for exhausted CD8(+) T cell stability and maintenance

Chronic stimulation of CD8(+) T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhausted cells exist in multiple differentiation states, from stem-like progenitors that are the key mediators of the response to checkpoint blockade, through to terminally...

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Detalles Bibliográficos
Autores principales: Wagle, Mayura V., Vervoort, Stephin J., Kelly, Madison J., Van Der Byl, Willem, Peters, Timothy J., Martin, Ben P., Martelotto, Luciano G., Nüssing, Simone, Ramsbottom, Kelly M., Torpy, James R., Knight, Deborah, Reading, Sinead, Thia, Kevin, Miosge, Lisa A., Howard, Debbie R., Gloury, Renee, Gabriel, Sarah S., Utzschneider, Daniel T., Oliaro, Jane, Powell, Jonathan D., Luciani, Fabio, Trapani, Joseph A., Johnstone, Ricky W., Kallies, Axel, Goodnow, Christopher C., Parish, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119420/
https://www.ncbi.nlm.nih.gov/pubmed/33986293
http://dx.doi.org/10.1038/s41467-021-23044-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119420/
https://www.ncbi.nlm.nih.gov/pubmed/33986293
http://dx.doi.org/10.1038/s41467-021-23044-9

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