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Biochemical and structural insights into Rab12 interactions with RILP and its family members

Alongside its biosynthetic functions, the small GTPase Rab12 negatively regulates mast cell (MC) exocytosis by its interaction with RILP to promote retrograde transport of the MC secretory granules. Given the role of Rab effectors in mediating Rab functions, in this study we used biochemical and in...

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Detalles Bibliográficos
Autores principales: Omar, Jana, Rosenbaum, Efrat, Efergan, Adi, Sneineh, Bayan Abu, Yeheskel, Adva, Maruta, Yuto, Fukuda, Mitsunori, Sagi-Eisenberg, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119438/
https://www.ncbi.nlm.nih.gov/pubmed/33986343
http://dx.doi.org/10.1038/s41598-021-89394-y