Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages, and identify the responsible genes. Using a...

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Detalles Bibliográficos
Autores principales: Robinet, Peggy, Ritchey, Brian, Lorkowski, Shuhui Wang, Alzayed, Alexander M., DeGeorgia, Sophia, Schodowski, Eve, Traughber, C. Alicia, Smith, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119501/
https://www.ncbi.nlm.nih.gov/pubmed/33986446
http://dx.doi.org/10.1038/s41598-021-89800-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119501/
https://www.ncbi.nlm.nih.gov/pubmed/33986446
http://dx.doi.org/10.1038/s41598-021-89800-5

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