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CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution

The pathway for the biosynthesis of the bacterial cell wall is one of the most prolific antibiotic targets, exemplified by the widespread use of β-lactam antibiotics. Despite this, our structural understanding of class A penicillin binding proteins, which perform the last two steps in this pathway,...

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Detalles Bibliográficos
Autores principales: Caveney, Nathanael A., Workman, Sean D., Yan, Rui, Atkinson, Claire E., Yu, Zhiheng, Strynadka, Natalie C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119973/
https://www.ncbi.nlm.nih.gov/pubmed/33986273
http://dx.doi.org/10.1038/s41467-021-23063-6