Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations

Sirtuin 2 (Sirt2) nicotinamide adenine dinucleotide-dependent deacetylase enzyme has been reported to alter diverse biological functions in the cells and onset of diseases, including cancer, aging, and neurodegenerative diseases, which implicate the regulation of Sirt2 function as a potential drug t...

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Detalles Bibliográficos
Autores principales: Bharadwaj, Shiv, Dubey, Amit, Kamboj, Nitin Kumar, Sahoo, Amaresh Kumar, Kang, Sang Gu, Yadava, Umesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119977/
https://www.ncbi.nlm.nih.gov/pubmed/33986372
http://dx.doi.org/10.1038/s41598-021-89627-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119977/
https://www.ncbi.nlm.nih.gov/pubmed/33986372
http://dx.doi.org/10.1038/s41598-021-89627-0

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