Cargando…

Evaluation of tradipitant, a selective NK1 antagonist, on response to oxycodone in humans

RATIONALE: Preclinical studies demonstrate that the NK1 receptor is involved in opioid reinforcement and withdrawal expression. Few studies have examined the impact of treatment with NK1 antagonists on opioid response in humans. OBJECTIVE: To explore the potential for a selective NK1 antagonist, tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coe, Marion A., Lofwall, Michelle R., Vessels, Victoria, Nuzzo, Paul A., Walsh, Sharon L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120018/ https://www.ncbi.nlm.nih.gov/pubmed/33988725 http://dx.doi.org/10.1007/s00213-021-05814-x

Ejemplares similares

Tradipitant in the Treatment of Motion Sickness: A Randomized, Double-Blind, Placebo-Controlled Study
por: Polymeropoulos, Vasilios M., et al.
Publicado: (2020)

Neurokinin‐1 receptor antagonist tradipitant has mixed effects on itch in atopic dermatitis: results from EPIONE, a randomized clinical trial
por: Welsh, S.E., et al.
Publicado: (2021)

1635. Do Persons With Opioid Use Disorder and Injection-Related Infections Really Need Prolonged Hospitalizations to Complete Intravenous Antibiotic Therapy?
por: Fanucchi, Laura, et al.
Publicado: (2018)

Risk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors
por: Yunusa, Ismaeel, et al.
Publicado: (2022)

Respiratory effects of oral mitragynine and oxycodone in a rodent model
por: Henningfield, Jack E., et al.
Publicado: (2022)

Limits to Genomic Divergence Under Sexually Antagonistic Selection
por: Kasimatis, Katja R., et al.
Publicado: (2019)

Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats
por: Pravetoni, Marco, et al.
Publicado: (2014)

Establishment of a new sex-determining allele driven by sexually antagonistic selection
por: Sakamoto, Takahiro, et al.
Publicado: (2020)

Ghrelin receptor antagonist JMV2959 blunts cocaine and oxycodone drug-seeking, but not self-administration, in male rats
por: Merritt, Christina R., et al.
Publicado: (2023)

Oxycodone and Dexamethasone for pain management after tonsillectomy: A placebo-controlled EMG assessed clinical trial
por: Vaiman, Michael, et al.
Publicado: (2011)

Association of Naloxone Coprescription Laws With Naloxone Prescription Dispensing in the United States
por: Sohn, Minji, et al.
Publicado: (2019)

Behavioral flexibility and response selection are impaired after limited exposure to oxycodone
por: Seip-Cammack, Katharine M., et al.
Publicado: (2014)

Telemedicine Buprenorphine Initiation and Retention in Opioid Use Disorder Treatment for Medicaid Enrollees
por: Hammerslag, Lindsey R., et al.
Publicado: (2023)

Effectiveness of Oxycodone Hydrochloride (Strong Opioid) vs Combination Acetaminophen and Codeine (Mild Opioid) for Subacute Pain After Fractures Managed Surgically: A Randomized Clinical Trial
por: Jenkin, Deanne E., et al.
Publicado: (2021)

Design and protocol of the Buprenorphine plus Outpatient Parenteral Antimicrobial Therapy (B-OPAT) study: a randomized clinical trial of integrated outpatient treatment of opioid use disorder and severe, injection-related infections
por: Fanucchi, Laura C., et al.
Publicado: (2022)

Effects of sex and estrous cycle on intravenous oxycodone self-administration and the reinstatement of oxycodone-seeking behavior in rats
por: Hinds, Nicole M., et al.
Publicado: (2023)

Effects of sex and estrous cycle on intravenous oxycodone self-administration and the reinstatement of oxycodone-seeking behavior in rats
por: Hinds, Nicole M., et al.
Publicado: (2023)

Accumulation of Deleterious Mutations Near Sexually Antagonistic Genes
por: Connallon, Tim, et al.
Publicado: (2016)

Use of Oxycodone in Pain Management
por: Moradi, Mohammad, et al.
Publicado: (2012)

Epidural Oxycodone for Acute Pain
por: Piirainen, Panu, et al.
Publicado: (2022)

What should be the protocol selection after failure of in-vitro fertilization at normoresponder patients: Agonist or antagonist?
por: Ceyhan, Seyit Temel, et al.
Publicado: (2014)

Quality of life under oxycodone/naloxone, oxycodone, or morphine treatment for chronic low back pain in routine clinical practice
por: Ueberall, Michael A, et al.
Publicado: (2016)

Changes in oxycodone and heroin exposures in the National Poison Data System after introduction of extended-release oxycodone with abuse-deterrent characteristics
por: Coplan, Paul M, et al.
Publicado: (2013)

Opioid-Induced Bowel Dysfunction in Patients Undergoing Spine Surgery: Comparison of Oxycodone and Oxycodone-Naloxone Treatment
por: Kokki, Merja, et al.
Publicado: (2016)

Incubation of Oxycodone Craving Following Adult-Onset and Adolescent-Onset Oxycodone Self-Administration in Male Rats
por: Altshuler, Rachel D., et al.
Publicado: (2021)

The NK1 antagonist L-733,060 facilitates sequence learning
por: Favila, Natalia, et al.
Publicado: (2023)

Adaptation of a standard extended-release naltrexone (XR-NTX) protocol for rural re-entering offenders with OUD
por: Staton, Michele, et al.
Publicado: (2021)

Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking
por: Wilkinson, Courtney S., et al.
Publicado: (2023)

Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking
por: Wilkinson, Courtney S., et al.
Publicado: (2023)

Characterization of the intergenerational impact of in utero and postnatal oxycodone exposure
por: Odegaard, Katherine E., et al.
Publicado: (2020)

A Network of Genes Antagonistic to the LIN-35 Retinoblastoma Protein of Caenorhabditis elegans
por: Polley, Stanley R. G., et al.
Publicado: (2012)

If it ain't broke, don't fix it: evaluating the effect of increased recombination on response to selection for wheat breeding
por: Taagen, Ella, et al.
Publicado: (2022)

Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis
por: Lazzari, Marzia, et al.
Publicado: (2015)

Colorectal Transit and Volume During Treatment With Prolonged-release Oxycodone/Naloxone Versus Oxycodone Plus Macrogol 3350
por: Poulsen, Jakob L, et al.
Publicado: (2018)

Relative Oral Bioavailability of an Abuse-Deterrent, Immediate-Release Formulation of Oxycodone, Oxycodone ARIR in a Randomized Study
por: Webster, Lynn R., et al.
Publicado: (2019)

Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats
por: Illenberger, Jessica M., et al.
Publicado: (2023)

Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
por: Mohammed Jawad, Rafat A., et al.
Publicado: (2017)

SAT-LB073 SJX-653, a Novel Selective NK3 Antagonist, Demonstrates Activity on Pharmacodynamic Markers of NK3 Target Engagement
por: Cormier, Jennifer, et al.
Publicado: (2019)

Differential Regulation of Antagonistic Pleiotropy in Synthetic and Natural Populations Suggests Its Role in Adaptation
por: Yadav, Anupama, et al.
Publicado: (2015)

Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
por: Recio, Rocío, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i9v1a7mh0at2cd5abr699kdmkj